CVE Intelligence
High Insecure deserialization

CVE-2026-100841 — MONAI through 1.6.0 PersistentDataset Remote Code Execution via Pickle Cache

In MONAI 1.6.0, PersistentDataset (monai/data/dataset.py) explicitly rejects the combination track_meta=True with weights_only=True, forcing users who cache MetaTensors (the default tensor type in MONAI >= 1.0) to run torch.load(hashfile, weights_only=False). Related cache helpers in monai/data/utils.py also call pickle.loads on cached content and derive cache keys with hashlib.md5. As a result, a local user with write access to a shared or world-writable cache_dir (e.g. /tmp/monai_cache, HPC scratch, ~/.cache/monai) can place a malicious pickle file that is deserialized the next time another user's MONAI pipeline reads the cache, resulting in arbitrary code execution in that user's context. All released versions of the monai pip package are affected; no patched version is available as of the advisory.

Published Sep 26, 2026 · Updated Oct 16, 2026 · Sources: NIST National Vulnerability Database, CVE Program (cve.org) e CISA ADP · CNA: VulnCheck

Who exploits it and how urgent it is

A 0–100 score combining confirmed exploitation, ransomware and APT use, public exploits, EPSS and severity.

No exploitation signal in the sources consulted so far.
How the score was calculated
  • EPSS 0.1% (30-day exploitation probability)+0
  • Technical severity (high)+6

The score orders the patch queue; it does not replace your asset context (internet exposure, criticality, compensating controls).

Triage

Is it exploited, how likely is exploitation, what does it touch, and how severe do the sources call it.

Exploitation
Not confirmed
Not in CISA KEV — an absence of record, not proof it is unexploited.
EPSS FIRST
0.13%
ahead of 2% of scored CVEs · Oct 15, 2026
Affects
Project-monai
Monai
CVSS base
7.8
High · 2 source(s)

CISA SSVC assessment CISA

Three decision points CISA publishes for the CVEs it assesses (SSVC 2.0.3). A stakeholder decision, not a severity score.

Exploitation
None
none · proof-of-concept · active
Automatable
No
can an attacker script the kill-chain steps
Technical impact
Total
partial · total control of the vulnerable component

Remediation

Fixes and mitigations documented by the sources — linked to the original advisory.

  • Documented mitigation — github.com (NIST National Vulnerability Database)

First 24 hours

Ordered from the record’s own fields — exposure first, because you cannot patch what you have not found. A rule-generated starting point.

  1. Identify exposed assets running the affected vendor/product/version combinations (Project-monai Monai).
  2. Apply the documented mitigations until a definitive fix is available.
  3. Search available logs for exploit probes matching the vulnerability class (insecure deserialization), errors and authentication anomalies.

Affected scope

Vendor, product and versions as the sources word them.

VendorProductVersionsStatusSource
Project-monai Monai version 1.6.0 Vulnerable NIST National Vulnerability Database
Project-monai Monai ≤ 1.6.0 Vulnerable CVE Program (cve.org) e CISA ADP

Attack characteristics

The CVSS vector, decoded. It describes the attack, not your exposure to it.

Attack vector
Local
Attack complexity
Low
Privileges required
Low
User interaction
None
Scope
Unchanged
Confidentiality
High
Integrity
High
Availability
High

Every base score collected

Sources score independently and may disagree; each row says who scored it and under which version.

ScoreVersionSeverityExpl.ImpactScored by
8.5 CVSS 4.0 High — — disclosure@vulncheck.com via NIST National Vulnerability Database
8.5 CVSS 4.0 High — — VulnCheck via CVE Program (cve.org) e CISA ADP
7.8 CVSS 3.1 High 1.8 5.9 disclosure@vulncheck.com via NIST National Vulnerability Database
7.8 CVSS 3.1 High — — VulnCheck via CVE Program (cve.org) e CISA ADP
CVSS:3.1/AV:L/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H (score shown at the top: disclosure@vulncheck.com)

Weakness MITRE

Weakness class according to MITRE’s CWE catalog.

CWE-502 · Deserialization of Untrusted Data

Other CVEs with this weakness →

Detection

Read off the CVSS vector and the weakness class. Starting points, not tested rules.

  • Local/physical vector: focus on endpoint telemetry (EDR) from affected hosts.
  • Monitor serialized objects in requests and unexpected processes spawned by the runtime.
endpoint telemetry (EDR)application logs

Timeline

What happened to this CVE, newest first.

  • 2026
  • Affected products added · project-monai/monai
    Oct 16, 2026 · CVE Program (cve.org) e CISA ADP
  • SSVC assessment updated
    Oct 16, 2026 · CVE Program (cve.org) e CISA ADP
  • Record published
    Oct 15, 2026
  • Fix documented
    Oct 15, 2026 · NIST National Vulnerability Database
  • CVSS changed · 7.8
    Oct 15, 2026 · NIST National Vulnerability Database
  • Source status changed · → Analyzed
    Oct 15, 2026 · NIST National Vulnerability Database
  • Record created in this database
    Oct 15, 2026 · NIST National Vulnerability Database
  • CVE published
    Sep 26, 2026 · VulnCheck

Source activity

Repeated readings are counted rather than listed.

  • 1× Official description updated · Oct 15, 2026 – Oct 15, 2026

References

2 on the record

Elsewhere on this site

Project-monai
every CVE for this vendor
Insecure deserialization
same class
CWE-502
other pages naming this weakness

Related CVEs (same products)

  • CVE-2026-109360 MONAI 0.4.0 before 1.6.1 RCE via SENet Pretrained Weights Over Plaintext HTTP 3d
  • CVE-2026-109361 MONAI 1.2.0 before 1.6.1 Insecure Deserialization RCE via nnUNetV2Runner postprocessing_file Path 3d
  • CVE-2026-100846 MONAI before 1.5.2 Remote Code Execution via Pickle Deserialization 19d
  • CVE-2026-100845 MONAI before 1.6.0 Remote Code Execution via NumpyReader 19d
  • CVE-2026-100840 MONAI through 1.6.0 Remote Code Execution via bundle configuration 19d
  • CVE-2026-100842 MONAI through 1.6.0 _get_fake_spatial_shape eval() Sandbox Bypass via Attribute Chains 19d

Not in any source we poll

Listed rather than left blank: an empty field and an unmeasured one look identical on screen, and only one is a reason to look elsewhere.

  • No confirmed IOCs, IP addresses, domains, file hashes, or malware artifacts supplied.
  • No organization-specific asset inventory, compensating-control status, or patch deployment evidence supplied.
  • No exploit packet captures, log samples, or incident case IDs supplied.

Answered from this record

Text assembled only from the fields above — no additional claims.

What should defenders know first?

CVE-2026-100841 is "MONAI through 1.6.0 PersistentDataset Remote Code Execution via Pickle Cache", rated High. It affects Monai (Project-monai); versions are in the scope table. It is not in CISA KEV, which does not rule out exploitation. CVSS 7.8 describes technical severity. EPSS 0.13% estimates the probability of exploitation in 30 days; neither replaces your asset context. First verify whether exposed or business-critical assets run the affected versions, apply vendor fixes or mitigations, and preserve logs for review.

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